Apoptosis Reagents and Kits
Meso Scale Discovery R-PLEX Human Annexin A5 ASYQP
The R-Plex Human Annexin A5 Assay from Meso Scale Diagnostics is a multiplex immunoassay that measures Annexin A5 levels in human serum plasma and cell culture supernatants It utilizes electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and requires low sample volume This assay allows for the quantitative measurement of Annexin A5 an important biomarker for apoptosis It can be used for research applications in oncology immunology cardiovascular disease and drug discovery and development The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer sample diluent and calibrator
Medchemexpress LLC N-carbobenzoxy-D-homoserine | 41088-85-1 | MFCD12545887 | 253.25 g/mol | C12H15NO5 | 5 G
N-Carbobenzoxy-D-homoserine (N-(Benzyloxycarbonyl)-D-homoserine) is the D-enantiomer of homoserine bearing an N-carbobenzoxy (Cbz) protecting group. Supplied as a powder, it is used as a synthetic intermediate in organic and peptide synthesis, including preparation of antibody-drug conjugates and other constructs that require temporary N-protection.
- Powdered synthetic intermediate for organic synthesis.
- Contains N-carbobenzoxy (Cbz) protecting group for the amino function.
- Suitable for peptide synthesis and antibody-drug conjugate payload or linker preparation.
- Molecular formula C12H15NO5; molecular weight 253.25 g/mol.
- Recommended storage: powder -20°C for long term, 4°C for short term.
AdipoGen Hoechst 33342
Chemical. CAS 23491-52-3. Formula C27H28N6O . 3HCl . xH2O. MW 561.93. Synthetic. Useful for staining DNA, chromosomes and nuclei. May be used for fluorescence microscopy or flow cytometry. Suitable for vital DNA staining of a variety of cell types and as a probe of membrane permeability in mammalian cells.
Abcam GSH/GSSG Ratio Detection Assay Kit (Fluorometric - Green)
GSH/GSSG Ratio Detection Assay Kit (Fluorometric - Green)
The product is subject to the following: Abcam Restricted Use Statement
Abcam Z-ATAD-FMK, Caspase-12 inhibitor, 1MG
MW 540.54 g/mol, Purity >95%. Specific caspase-12 inhibitor. Suppresses annular cell apoptosis and caspase-9 activity in vitro. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam APOBRDU-IHC DNA FRAGMENTATION ..
APOBRDU-IHC DNA FRAGMENTATION ..
The product is subject to the following: Abcam Restricted Use Statement
Meso Scale Discovery Apoptosis Whole Cell Lysate
The Mesoscale Apoptosis Whole Cell Lysate Kit (K15102D) is a multiplex assay kit that allows for the simultaneous detection of cleaved PARP cleaved caspase-3 phospho-p53 (S15) and total p53 from cell lysates The kit contains a 96-well plate coated with capture antibodies detection antibodies and buffers needed to run the assay This assay kit enables high-throughput quantitative analysis of apoptotic markers and p53 activation status in cells It is compatible with lysates from human mouse and rat samples The kit provides all necessary reagents to analyze 46 samples in duplicate
ABclonal Technology Caspase-1 Rabbit pAb
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
ABclonal Technology Annexin A5/Annexin V Rabbit mAb
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.
Apexbio Technology LLC A-1155463 1235034-55-5 5mg
A-1155463 (CAS 1235034-55-5) is a potent and selective small-molecule inhibitor of the anti-apoptotic protein BCL-XL exhibiting a Ki of 19 nM Developed through NMR fragment screening and structure-guided optimization A-1155463 demonstrates higher efficacy against BCL-XL-dependent cell lines compared to earlier inhibitors such as WEHI-539 In murine models administration of A-1155463 induces transient thrombocytopenia and inhibits the growth of BCL-XL-dependent H146 xenograft tumors supporting its utility for mechanistic studies on BCL-XL in tumor cell survival and therapeutic resistance The compound remains in preclinical research stages
Abcam Human DPT Antibody Pair - BSA and Azide free (TRAMP), 10 x 96 Tests
Human DPT Antibody Pair - BSA and Azide free (TRAMP) is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human DPT (TRAMP).
The product is subject to the following: Abcam Restricted Use Statement